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Cat. Number
H62510
Chemical Name
C2 Ceramide (d18:1/2:0)
CAS Number
3102-57-6
Mol. Formula
C20H39NO3
Mol. Weight
341.5
Qty 1
10mg
Qty 2
25mg
Appearance
A crystalline solid
Application Notes
≥98%
Synonym
C2 Ceramide;Ceramide (d18:1/2:0);Cer(18:1/2:0);N-acetoyl-D-erythro-sphingosine;N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-acetamide
Solubility
DMSO: >20 mg/ml (from C-8 Ceramide);DMF: >22 mg/ml (from C-8 Ceramide)
Storage condition
-20°C
Stability
≥ 1 year
References

C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells,1 induction of apoptosis,2 activation of protein phosphatase 2A,3 and inhibition of the mitochondrial respiratory chain.4 C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts5 and stimulates the growth of bovine aortic smooth muscle cells.6 The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.7

神经酰胺是由神经鞘氨醇长链碱基与脂肪酸组成神经鞘氨脂质一种。神经酰胺(Ceramide)是以神经酰胺为骨架的一类磷脂,主要有神经酰胺磷酸胆碱和神经酰胺磷酸乙醇胺,磷脂是细胞膜的主要成分,神经酰胺(Ceramides, Cers)存在于所有的真核细胞中,对细胞分化、增殖、凋亡、衰老等生命活动具有重要调节作用。

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C2 Ceramide (d18:1/2:0)

C6 Ceramide-d7 (d18:1-d7/6:0)

C16 Ceramide-d7 (d18:1-d7/16:0)

C18 Ceramide-d7 (d18:1-d7/18:0)

C24 Ceramide-d7 (d18:1-d7/24:0)

C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))




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