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Cat. Number
1257
Chemical Name
9(E),11(E)-十八碳二烯酸甲酯 Methyl 9(E),11(E)-octadecadienoate
CAS Number
13038-47-6
Mol. Formula
C19H34O2
Mol. Weight
294
Qty 1
25mg
Appearance
liquid
Application Notes
98+% GC, TLC, identity confirmed by MS
Synonym
Methyl ester of CLA (9 trans, 11 trans)
Solubility
ethanol, methanol, hexane, chloroform
Storage condition
-20°C
References

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9(Z),11(E)-十八碳二烯酸 9(Z),11(E)-Octadecadienoic acid 25mg

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9(E),11(E)-十八碳二烯酸 9(E),11(E)-Octadecadienoic acid 25mg

9(E),11(E)-十八碳二烯酸甲酯 Methyl 9(E),11(E)-octadecadienoate 25mg

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9(Z), 11(Z)十八碳二稀酸甲酯 Methyl 9(Z), 11(Z)-octadecadienoate 25mg

Application Notes:

This product is a methyl ester of 9(E),11(E)-Octadecadienoic acid, a conjugated linoleic acid (CLA) which is an isomer of linoleic acid. CLA is found mostly in lipids originating in ruminant animals including dairy products. It has several biological properties including anti-carcinogenic activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. 9(E),11(E)-CLA is a minor component in natural sources of CLA and is used as a marker for free radical activity. Also, due to its being a minor component it is very helpful as a comparison to the major isomers 9(Z),11(E)-CLA and 10(E),12(Z)-CLA. 9(E),11(E)-CLA can exert antiinflammatory effects by increasing an endogenous repressor of IL-1 signaling2. It can induce expression of genes involved in lipid metabolism of human macrophages and is a dietary occurring agonist of liver X receptor alpha.3

参考文献References:
1. H. MacDonald “Conjugated Linoleic Acid and Disease Prevention: A Review of Current Knowledge” Journal of the American College of Nutrition, Vol. 19 pp. 111S-118S, 2000
2. Y. Lee, J. Thompson and J. Heuvel “9E,11E-Conjugated Linoleic Acid Increases Expression of the Endogenous Antiinflammatory Factor, Interleukin-1 Receptor Antagonist, in RAW 264.7 Cells” The Journal of Nutrition, Vol. 139:10 pp. 1861-1866, 2009
3. J. Ecker et al. “The conjugated linoleic acid isomer trans-9,trans-11 is a dietary occurring agonist of liver X receptor alpha” Biochemical and biophysical research communications, Vol. 388:4 pp. 660-666, 2009


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